Margriet Kwint

The work described in this thesis was performed at the Netherlands Cancer Institute – Antoni van Leeuwenhoek, Amsterdam, The Netherlands ISBN: 978-94-6416-441-1 Cover design: Bernice Timmers Lay-out: Publiss | www.publiss.nl Print: Ridderprint | www.ridderprint.nl Copyright: ©Margriet H. Kwint, Amsterdam, The Netherlands All rights reserved. No part of this publicationmay be reproduces, stored of transmitted in any form or by any means without prior permission of the holder of the copyright. Financial support for printing of this thesis has kindly been provided by The Netherlands Cancer Institute – Antoni van Leeuwenhoek, ChipSoft and Boehringer Ingelheim bv