Margriet Kwint

Appendices 178 nodes (chapter 2). Data of 217 patients were analyzed. The conclusions of this study were that the use of real world data provides a useful method for quality assurance and for validation of NTCP-models in clinical practice. Both V50 and V60 NTCP-models showed moderate accuracy to predict acute esophageal toxicity in NSCLC patients. For clinical practice, the V50 seems to be the most stable dose volume parameter without compromising safety and efficacy after dose de-escalation. Finally, chapter 8 provides the general discussion of this thesis.