Anna Brouwer

Prolonged cone b-IT in relation to retinal layer analysis OCT thickness analysis Table 2 shows in shaded grey the results of the IPL, INL, and OPL, the layers which encompass the bipolar cells. In eyes with a prolonged cone b-IT, the mean thickness of the IPL was significantly thinner in seven regions of the ETDRS grid (regions 2, 3, 5 - 9). In contrast, the INL layer was significantly thicker in the six central regions of the ETDRS grid (regions 1 - 6) in eyes with a prolonged cone b-IT. No differences were observed in the OPL. Table 3 gives an overview of Spearman’s rho correlation coefficients of implicit times in ms of the different flash strengths in relation to the thickness in microns of the IPL and INL. In line with the findings in Table 2, these correlations between thickness and implicit time were often statistically significant, but the correlation coefficients were weak ranging between 0.103 and 0.388. Weak correlations were also found between the thickness of the INL and IPL and clinical parameters that were previously found to be associated with a prolonged cone b-IT (Table 4). 5 Besides the retinal layers which contain the bipolar cells, other layers also showed significant differences in thickness in eyes with a prolonged cone b-IT (Table 2). The retinal nerve fiber layer (RNFL) was significantly thicker (Table 2). Glaucoma, a common complication of uveitis, was investigated as a possible confounder for the differences in the RNFL thickness. Eyes with glaucoma (n = 67 eyes) had a significantly thicker RNFL in regions 1, 7 and 9 and a thinner GCL and IPL in regions 2 to 9. Eyes with glaucoma also had a thicker INL (region 3, 7), similarly to eyes with a prolonged cone b-IT. However, when eyes with glaucoma were excluded and a comparison was made between eyes with a prolonged cone b-IT, a normal cone b-IT, and non-uveitis eyes, the IPL was still significantly thinner and the INL was thicker in eyes with a prolonged cone b-IT. The other layers also showed similar outcomes when glaucoma eyes were excluded. The outer retinal layers showed significant differences as well (Table 2). The largest differences were observed between the non-uveitis eyes and uveitis eyes with a prolonged cone b-IT. The results of the uveitis eyes with a normal cone b-IT lay in between, but their retinal layer thicknesses were closer to those of the non-uveitis eyes. When the non-uveitis eyes were excluded, and only the differences between uveitis eyes with and without a prolonged cone b-IT were compared, similar outcomes were observed. Regarding the layers containing bipolar cells, the only different outcome was that the INL was no longer significantly thicker in region 3. 99 4