Anna Brouwer

Chapter 3 90 Cells AC 1 st ERG Active FU ERG a Media opac./pupil <6mm 1 st ERG b Media opac./pupil <6mm FU ERG b Age Duration of uveitis 1 st ERG Duration of uveitis FU ERG Syst. Med 1 st ERG Syst. Med FU ERG Improved IT Worsened IT Cells AC 1 st ERG rho 1,000 0,084 0,144 0,176 0,031 ,286 ** 0,179 -0,079 0,194 ,362 ** -0,137 p-value 0,425 0,163 0,099 0,768 0,005 0,086 0,445 0,060 0,000 0,187 Active FU ERG a rho 0,084 1,000 0,146 ,354 ** ,258 * 0,055 0,049 0,103 0,149 0,090 ,318 ** p-value 0,425 0,164 0,001 0,011 0,595 0,636 0,319 0,147 0,383 0,002 Media opac./ pupil <6mm 1 st ERG b rho 0,144 0,146 1,000 ,257 * ,337 ** 0,006 -0,050 -0,182 0,021 ,462 ** -0,026 p-value 0,163 0,164 0,015 0,001 0,954 0,631 0,077 0,840 0,000 0,805 Media opac./ pupil <6mm FU ERG b rho 0,176 ,354 ** ,257 * 1,000 0,188 ,236 * ,218 * -0,117 -0,006 ,206 * ,214 * p-value 0,099 0,001 0,015 0,073 0,024 0,038 0,267 0,954 0,049 0,040 Age rho 0,031 ,258 * ,337 ** 0,188 1,000 -0,082 -0,136 -0,046 0,030 0,198 -0,034 p-value 0,768 0,011 0,001 0,073 0,429 0,187 0,654 0,770 0,051 0,740 Duration of uveitis 1 st ERG rho ,286 ** 0,055 0,006 ,236 * -0,082 1,000 ,831 ** -0,134 0,180 0,041 0,081 p-value 0,005 0,595 0,954 0,024 0,429 0,000 0,194 0,080 0,696 0,433 Duration of uveitis FU ERG rho 0,179 0,049 -0,050 ,218 * -0,136 ,831 ** 1,000 -,234 * 0,002 0,134 0,029 p-value 0,086 0,636 0,631 0,038 0,187 0,000 0,023 0,982 0,194 0,782 Syst. med 1 st ERG rho -0,079 0,103 -0,182 -0,117 -0,046 -0,134 -,234 * 1,000 ,470 ** -0,135 0,067 p-value 0,445 0,319 0,077 0,267 0,654 0,194 0,023 0,000 0,186 0,510 Syst. med FU ERG rho 0,194 0,149 0,021 -0,006 0,030 0,180 0,002 ,470 ** 1,000 -0,014 -0,014 p-value 0,060 0,147 0,840 0,954 0,770 0,080 0,982 0,000 0,893 0,893 Improved IT rho ,362 ** 0,090 ,462 ** ,206 * 0,198 0,041 0,134 -0,135 -0,014 1,000 -0,114 p-value 0,000 0,383 0,000 0,049 0,051 0,696 0,194 0,186 0,893 0,265 Worsened IT rho -0,137 ,318 ** -0,026 ,214 * -0,034 0,081 0,029 0,067 -0,014 -0,114 1,000 p-value 0,187 0,002 0,805 0,040 0,740 0,433 0,782 0,510 0,893 0,265 Supplemental table 4: Correlation matrix of significant clinical factors, as well as systemic medication, duration of uveitis, and age Correlation matrix of clinical factors that had a statistically significant association with changes in the implicit time of the cone b-wave as well as systemic medication, duration of uveitis, and age. Correlations were calculated using Spearman’s rho. The first ERG was measured <1 year of uveitis diagnosis and the follow-up ERG 1 year later. a) Defined as the presence of cells in the AC and/or a vitritis of ≥ 1+ cells and/or a FA score of >1. b) Defined as opacities of the lens/ IOL and/or vitreous opacities and/or a pupil size of <6mm. Abbreviations: ERG = electroretinogram, 1 st = first, FU = follow-up, BCVA = best corrected visual acuity, AC = anterior chamber, IOL = intraocular lens, opac. = opacities, syst. = systemic, IT = implicit time of the cone b-wave.