Anna Brouwer

Chapter 3 78 Uveitis activity and vision of eyes with a prolonged cone b-wave at their first ERG At time of first ERG a At time of follow-up ERG b Improved at time of FU ERG (n = 10) Stable at time of FU ERG (n = 25) Worsened at time of FU ERG (n = 5) p-value Improved at time of FU ERG (n = 10) Stable at time of FU ERG (n = 25) Worsened at time of FU ERG (n = 5) p-value Active, N (%) c 9 (90) 20 (80) 4 (80 0.847 4 (40) 9 (36) 4 (80) 0.210 BCVA, median [IQR] 0.12 [0.01, 0.22] 0.15 [0.05, 0.40] 0.15 [0.10, 0.52] 0.598 0.36 [0.04, 0.52] 0.15 [0.00, 0.40] 0.22 [0.15, 0.52] 0.566 Flare, N (%) 1 (10) 0 0 0.375 0 2 (8) 1 (20) 0.464 Cells AC, N (%) 5 (50) 3 (12) 0 0.030 0 0 1 (20) 0.125 Anterior uveitis 1 (10) 0 0 0 0 0 anuveitis 4 (40) 3 (12) 0 0 0 1 (20) Vitritis, N (%) 5 (50) 11 (44) 2 (40) >.999 3 (30) 6 (24) 3 (60) 0.291 Anterior uveitis 1 (10) 0 0 0 0 0 Intermediate uveitis 1 (10) 0 0 0 2 (8) 0 Posterior uveitis 3 (30) 5 (20) 2 (40) 2 (20) 4 (16) 3 (60) Panuveitis 0 6 (24) 0 1 (10) 0 0 CME on OCT, N(%) 4 (40) 8 (32) 2 (40) 0.894 0 5 (20) 2 (40) 0.155 Mean deviation VF, median [IQR] -15.1 [-15.1, -15.1] -3.7 [-6.2, -1.5] -4.9 [-7.5, -4.2] 0.462 -2.1 [-2.4, -1.9] -4.4 [-7.5, -2.8] -7.5[-7.7, -5.1] 0.212 FA score 3mnd, median [IQR] 12.5 [6.8, 17.3] 6.0 [3.8, 9.5] 1.5 [0.8, 2.3] 0.095 11.0 [7.8, 12.5] 2.0 [1.5, 6.0] 20.0 [10.5, 20.0] 0.424 Media opacities and/or small pupil size N(%) d 8 (80) 5 (20) 0 <0.001 6 (24.0) 5 (63) 5 (100) 0.001 Table 3. Uveitis activity and vision of eyes (40) with a prolonged cone b-wave during their first electroretinogram Clinical characteristic during the first and FU ERG of eyes with a prolonged cone b-wave during their first ERG. Eyes with a pupil size difference > 1 mm between the first and the follow-up ERG were excluded. Statistical testing was done with Fischer’s exact test in case of categorical variables and Mann-Whitney-U test in case of continuous variables. All tests were two-tailed. Data are presented as N (%), unless otherwise specified. a) < first year of uveitis activity. b) > 1 year later. c) Defined as the presence of cells in the AC and/or a vitritis of ≥.1+ cells and/or a FA score of >.1. d) Defined as opacities of the lens/IOL and/or vitreous opacities and/or a pupil size of < 6 mm. Abbreviations: N = number, IQR = interquartile range, AC = anterior chamber, CMO = cystoid macula oedema, OCT = optical coherence tomography, VF = visual field, FA = fluorescein angiography, FU = follow-up, IOL = intraocular lens, ERG = electroretinogram.