Anna Brouwer

3 77 ERG abnormalities in non-infectious uveitis often persist Prolonged cone b-wave first ERG Normal cone b-wave first ERG Improved during FU ERG (n=8) Stable during FU ERG (n=16) Worsened during FU ERG (n=4) p-value Stable during FU ERG (n=30) Worsened during FU ERG (n=5) p-value Age a , median [IQR] 60.97 [54.40, 67.00] 59.21 [52.13, 67.91] 51.58 [44.92, 61.43] 0.694 35.10 [25.26, 52.26] 49.56 [40.45, 53.93] 0.239 Male gender, N (%) 6 (37.5) 5 (62.5) 1 ( 25.0) 0.492 11 (36.7) 3 (60.0) 0.369 Bilateral uveitis, N (%) 11 (68.8) 5 (62.5) 2 ( 50.0) 0.863 14 (46.7) 3 (60.0) 0.658 Localisation, N (%) 0.241 0.119 Anterior 0 1 (12.5) 0 1 ( 3.3) 0 Intermediate 2 (12.5) 1 (12.5) 0 1 ( 3.3) 2 (40.0) Posterior 7 (43.8) 5 (62.5) 4 (100.0) 18 (60.0) 2 (40.0) Panuveitis 7 (43.8) 1 (12.5) 0 10 (33.3) 1 (20.0) Daignosis, N (%) 0.364 0.555 Unknown cause 9 (56.2) 6 (75.0) 1 ( 25.0) 8 (26.7) 3 (60.0) Chorioretinitis 1 ( 6.2) 0 ( 0.0) 1 ( 25.0) 10 (33.3) 1 (20.0) Sarcoidosis 2 (12.5) 2 (25.0) 0 6 (20.0) 0 Birdshot 2 (12.5) 0 ( 0.0) 2 ( 50.0) 2 ( 6.7) 1 (20.0) VKH 1 ( 6.2) 0 0 0 0 Behcet 0 0 0 1 (3) 0 Systemic med 1 st ERG, N (%) 8 (50.0) 3 (37.5) 3 ( 75.0) 0.514 14 (46.7) 1 (20.0) 0.365 Systemic med FU ERG, N (%) 11 (68.8) 4 (50.0) 3 ( 75.0) 0.551 4.46 (6.76) 1.10 (1.42) 0.502 Time start systemic med, median [IQR] b 5.57 (5.95) 4.93 (6.25) 2.86 (3.43) 0.777 1.73 [1.46, 1.92] 1.65 [1.40, 1.86] 0.576 Table 2. Patient characteristics of uveitis patients with different outcomes of the implicit time of the cone b-wave In case of a bilateral uveitis, one eye per patient was analysed. When both uveitis eyes had the same cone b-wave outcome (i.e. both uveitis eyes stabile, or both improved, or both worsened), one eye was selected at random. If the cone b-wave outcome differed between uveitis eyes in patients with a bilateral uveitis, the eye with the changed cone b-wave outcome (i.e. improved or worsened) was selected for analysis of patient specific variables such as age or diagnosis. None of the patients had one eye with an improved ERG and one eye with a worsened ERG. a) In years. b) Time in months between the onset of uveitis and the start of systemic medication. Abbreviations: FU = follow-up, N = number, IQR = interquartile range, 1 st = first, ERG = electroretinogram, med = medication.