Anna Brouwer

Chapter 3 76 patients with a normal first ERG (median uveitis duration on months of 1.2 versus 2.9, respectively, p = 0.382). This difference was not significant and overall patients with an abnormal first ERG were treated more often with systemic medication. Also, we observed no differences based on uveitis diagnosis. Table 3 shows possible associations for an improved implicit time of the cone b-wave and uveitis characteristics. Eyes with an improved implicit time more often had a panuveitis with cells in the anterior chamber during the first ERG. This inflammation in the anterior chamber was resolved during the second ERG in all improved eyes. Table 4 shows possible associations between a worsening of the implicit time of the cone b-wave in eyes with an initial normal ERG and uveitis characteristics. Eyes that had a worsened ERG, more frequently had an active uveitis during the second ERG. This activity was mostly due to a vitritis, which was often not present during the first ERG. Besides vitritis, BCVA of these eyes was on average also slightly worse during the first ERG, but improved during the follow-up ERG. Eyes with an improved ERG had more frequently media opacities and/or a small pupil size during the first ERG, whereas eyes with a worsened ERG had these findings more frequently during the second ERG. Figure 1: Examples of a patient with a worsened (A) implicit time of the cone b-wave, and of a patient with an improved implicit time of the cone b-wave (B). The first ERG is printed in grey and the follow-up ERG a year later in black. a a 0 30 60 90 120 ms 50µV µV First ERG Follow-up ERG 0 30 60 90 120 ms 50µV µV Worsened implicit time of the cone b-wave A Improved implicit time of the cone b-wave B First ERG Follow-up ERG 10.0 cds/m 2 3.0 cds/m 2 1.0 cds/m 2 0.3 cds/m 2 10.0 cds/m 2 3.0 cds/m 2 1.0 cds/m 2 0.3 cds/m 2 b b b b b b b b b b b b b b b b a a a a a a a a a a a a a a