Anna Brouwer

3 75 ERG abnormalities in non-infectious uveitis often persist On a group level, the implicit times of the cone b-wave were not statistically significantly different between the first and the follow-up ERG (see Table 1). The ERG changed significantly in 20 eyes: in 10 eyes the implicit time improved and in 10 eyes it worsened, based on our cut-off values (see Figure 1 for examples). There was no predominant flash strength at which this change in implicit time was most prominent. In other ERG parameters (see Supplemental table 1), there were also no consistent significant changes between the first and the follow-up ERG. There was a significant correlation between the peak implicit time of the 30Hz flicker response and a prolonged cone b-wave of both the first (Spearman’s rho = 0.739, p < 0.001) and follow-up ERG (Spearman’s rho = 0.695, p < 0.001) Implicit time cone b-wave, median [IQR] 1 st ERG (< 1 year of diagnosis) Follow-up ERG (< 1 year later) P-value cds/m 2 0.3 27.00 [25.50, 30.50] 27.00 [26.00, 30.38] 0.544 1.0 29.25 [28.00, 31.00] 29.25 [28.00, 31.00] 0.960 3.0 31.50 [30.62, 33.50] 32.00 [31.00, 33.50] 0.760 10.0 35.50 [35.00, 37.50] 35.75 [35.00, 37.00] 0.510 Table 1: Results of implicit time of the cone b-wave of the first and follow-up electroretinogram Results of the first and follow-up ERG of the different flash strengths (cds/m 2 ) of the implicit time of the cone b-wave of 98 uveitis eyes. Eyes with a pupil size difference > 1 mm between the first and the follow-up ERG were excluded. Results of the other ERG parameters are shown in supplementary table 1. P-values were tested with the paired Wilcoxon signed rank test (no normal distribution of data). All significances were two-tailed. Abbreviations: ERG = electroretinogram, IQR = interquartile range, cds/m 2 = candela · seconds/squared meters. ERG changes in relation to clinical parameters Table 2 shows possible associations between changes in the ERG and patient characteristics as well as treatment. Regarding age, gender, anatomical localization, and uveitis diagnosis there were no differences in changes in the implicit time of the cone b-wave. We also observed no statistically significant differences in treatment between patients with a different ERG outcome. However, more patients that had an improved follow-up ERG were treated with systemic medication after the first ERG. In contrast, one of the patients with a worsened ERG ceased systemic medication between the first and follow-up ERG. There was no significant association between the duration of uveitis and start of systemic medication with either an improvement or a worsening of the ERG. However, patients with an abnormal first ERG, started systemic medication later compared to