Anna Brouwer

Considering the current findings and previous reports, we emphasize that in non- anterior childhood uveitis the global inner retinal function is frequently affected. Even though ERG abnormalities in intermediate and childhood uveitis have been reported in the past, ERG outcomes were not investigated in relation to clinical parameters as shown in our study. We recommend using an extended ISCEV protocol to detect early and subtle retinal dysfunction. If an association between ERG abnormalities and long-term visual outcome can be made in the future, these early ERG findings during the course of childhood uveitis have significance for treatment strategies. Since ERG abnormalities occur when BCVA is still relatively good, further studies should focus on the effects of this retinal dysfunction on long term visual outcome. Acknowledgements Contributors: All the authors have contributed to the acquisition, analysis and interpretation of data and writing or revising of the manuscript. Competing Interests: All authors report no competing interests. The author was supported by the following foundations: Dr. F.P Fischer Stichting and Vereniging Bartiméus Sonneheerdt that contributed through UitZicht. The funding organizations had no role in the design or conduct of this research. They provided unrestricted grants. We thank all patients and/or their parents for granting permission to use their medical files for this publication. We thank F.C.C. Riemslag for his help in reviewing this article and P. Zuidhof for statistical advice. 120 Chapter 5