Anna Brouwer

ERG abnormalities in non-anterior childhood uveitis Eyes with ERG abnormalities x n=29 Eyes without ERG abnormalities x n=34 P-value all eyes p-value worst eye e Male 16 (55) 14 (41) .267 .565 Age in years a,b 11.4 (9.5 -13.2) 14.8 (11.9 - 15.8) .016* .067 Duration of uveitis in years a,b 1.7 (.7 - 6.4) 3.4 (1.5 - 7.3) .267 .908 Blau syndrome 1 (3) 5 (15) .112 .438 History of CME 17 (59) 12 (36) .080 .309 3+ vitreous cells b,c 7 (24) 0 .001** .026** 3+ cells in anterior chamber b,c 2 (7) 0 .075 .266 CME b 7 (24) 0 .001** .021** Hyperemic optic disc b 9 (31) 3 (9) .023* .173 Vitreous haze b,c 8 (28) 7 (21) .516 .602 BCVA in LogMAR a,b 0.10 (0.00 - 0.40) 0.05 (0.00 - 0.11) .127 .133 Oral Prednisone 21 (72) 28 (82) .345 .602 Methotrexate 11 (38) 17 (50) .337 .246 Adalimumab 5 (17) 7 (21) .735 .805 Mycofenolaatmofetil 12 (41) 12 (35) .620 .948 Peribulbar steroid injections 15 (52) 15 (44) .547 >.999 FA total score a,d 11.0 (5.0 -17.0) 8.0 (1.8 - 12.0) .108 .461 FA capillary leakage score a,d 5.0 (0-10.0) 2.0 (0 - 5.3) .148 .265 FA CME a,d 17 (65) 13 (43) .137 .309 FA vasculitis a,d 16 (59) 19 (63) .752 .466 FA optic disc leakage a,d 23 (85) 23 (76) .413 .391 Table 2. Clinical characteristics of uveitis eyes in relation to electroretinogram abnormalities x) ERG abnormalities are defined as prolonged implicit times of the light adapted (0.3 - 10.0 cds/m 2 ) cone b-wave and/or abnormalities of the 30 Hz flicker (amplitudes/implicit times). Data are given as number (%) unless otherwise stated. a) Data given as median (IQR). b) Present at closest outpatient visit to ERG measurement. c) As described by the Standardization of Uveitis Nomenclature classification. d) FAs with the highest score were used for calculation of FA scores as described by The Angiography Scoring for Uveitis Working Group. e) Only none eye per patient was used, in case of bilateral uveitis, eyes with the worst BCVA were selected, when BCVA was the same, eyes were selected at random. * significant in one of two analysis ** significant in both analyses. Abbreviations: ERG = electroretinography, N = number; BCVA = best corrected visual acuity, LogMAR = logarithm of minimal angle of resolution, CME = cystoid macular edema, FA = fluorescein angiography. 117 5