Aurelie Lange

This thesis has been facilitated by an unrestricted grant of ZonMW and with support of de Viersprong. ISBN 978-94-6299-798-1 Design of the cover: Yannick Lange Printing: Ridderprint, the Netherlands Layout Design: Ridderprint, the Netherlands Copyright © 2017 Aurelie Lange, Rotterdam, the Netherlands. All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.