Bibian van der Voorn

The printing of this thesis was generously supported by Nutricia Early life Nutrition, Pfizer Innovative Health, Hero Benelux, Ipsen Farmaceutica B.V. and Stichting Researchfonds Kindergeneeskunde. Cover Bibian Metselaar - van der Voorn, inspired by the image called “Albert” by Anne Geddes, created for March of Dimes. Lay-out Nikki Vermeulen | Ridderprint BV Printing Ridderprint BV | www.ridderprint.nl Copyright © 2017 Bibian Metselaar - van der Voorn All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.